Streptococcus pneumoniae IgG Antibodies, Total, with Reflex, Serum
Use
This test is used for assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent, 20-valent pneumococcal vaccines, and nonconjugated 23-valent pneumococcal vaccines. It evaluates the body's ability to produce an antibody response to polysaccharide antigens, aiding in the assessment of humoral or combined immunodeficiencies. The test provides insights into the immune response following pneumococcal vaccination, which is essential for identifying potential immune deficiencies in patients with intrinsic defects in humoral immunity or specific antibody deficiency.
Special Instructions
Not provided.
Limitations
The test does not define protective IgG antibody concentrations against Streptococcus pneumoniae. Quantitation of IgG antibody response does not provide information on functional capacity such as opsonization efficiency. Factors that can affect the test include age, immune status, vaccination history, prior infections, and carrier status. It does not diagnose specific diseases but helps to understand immunoglobulin deficiencies.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Streptococcus pneumoniae IgG
Protein
LOINC Codes
- 43236-9 - S pneum IgG Ser IA-mCnc
- 43236-9 - S pneum IgG Ser IA-mCnc
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Heat-inactivated specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |