Use

This test is useful for serial monitoring of CD4 T-cell count in patients who are HIV-positive, as well as for follow-up and diagnostic evaluation of primary immunodeficiencies, including severe combined immunodeficiency. It is also utilized for immune monitoring after immunosuppressive therapy for transplantation, autoimmunity, and other immunological conditions. It helps in the assessment of immune reconstitution post-hematopoietic cell transplantation and early screening of gross quantitative anomalies in lymphocyte subsets caused by infections or malignancies. Additionally, it provides absolute quantitation of circulating B cells for diagnosing patients with chronic lymphocytic leukemia as per guidelines from the 2008 International Workshop on Chronic Lymphocytic Leukemia.