T-Cell Lymphoblastic Leukemia/Lymphoma, FISH, Tissue
Use
This test is useful for detecting recurrent chromosome abnormalities associated with T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) in paraffin-embedded tissue specimens, and for monitoring response to therapy by tracking known chromosome abnormalities in patients with T-ALL/T-lymphoblastic lymphoma.
Special Instructions
Not provided.
Limitations
The test is not approved by the FDA and is best used as an adjunct to existing clinical and pathologic information. Non-formalin fixed specimens and decalcified tissues have a lower success rate. Insufficient tumor presence or lack of FISH signal post-hybridization can result in cancellation or inconclusive results.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101663-3 - TALAF Bld/T FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tumor tissue block or slides
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Blocks prepared with alternative fixation methods will be attempted but are less favorable for successful results; provide fixation method used. For tissues, include 1 hematoxylin and eosin-stained slide and additional unstained slides for each probe set if individual probes are requested.
Causes for Rejection
Suitability will be evaluated at Mayo Clinic Laboratories.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Preferred |