T-Cell Lymphoma, Specified FISH, Varies
Use
This test is useful for detecting common chromosome abnormalities associated with specific T-cell lymphoma subtypes using client-specified probe sets. It assists in the diagnosis of T-cell malignancies such as T-cell prolymphocytic leukemia and hepatosplenic T-cell lymphoma. Genetic abnormalities detected by FISH can act as important prognostic markers and aid in determining specific T-cell lymphoma subtypes.
Special Instructions
This test should be ordered with a specific list of FISH probes to be analyzed. It should only be ordered if the specimen is known to have a sufficient clonal T-cell population. If flow cytometry results show insufficient clonal T-cells, the test will be canceled. The probes used for certain subtypes of T-cell lymphoma must be specified and consent for reflex testing must be indicated.
Limitations
This test is not intended for use as a screening tool for residual T-cell lymphoma. It is limited to analyzing client-specified FISH probes. Failure to specify targeted FISH probes on the test order may delay test processing. The test is designed for blood and bone marrow specimens; using paraffin-embedded tissue specimens requires a different test. Analytical limitations include the scope of detection for specific chromosome abnormalities defined by the selected probes.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101682-3
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 78040-3
- 31208-2
- 85069-3
- 48767-8
- 62364-5
- 18771-6
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD), Green top (sodium heparin), or Lavender top (EDTA)
Collection Instructions
Preferably send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow and send in original tube. Do not aliquot.