Tetanus Toxoid IgG Antibody, Serum
Use
The Tetanus Toxoid IgG Antibody test is used to assess the antibody response to the tetanus toxoid vaccine, usually performed at least three weeks after immunization. It aids in the evaluation of immunodeficiency by measuring the presence and concentration of IgG-class antibodies to tetanus toxoid in serum. A positive result indicates a successful immunological response to the vaccine, while absence of antibodies may suggest an underlying immune deficiency. This test is not intended for diagnosing an active tetanus infection.
Special Instructions
Ensure that the sample is collected at least three weeks post vaccination. Use a serum gel or red top collection container, and transfer serum to a plastic vial. If not ordering electronically, complete and send the Infectious Disease Serology Test Request form with the specimen.
Limitations
This test should not be used for diagnosing tetanus infection, as it is not a direct measure of immunity or vulnerability to tetanus. Diagnosis of tetanus is based on clinical observations. Positive wound culture results for Clostridium tetani or toxin assays for tetanospasmin are necessary for supporting a clinical diagnosis, though they are not definitive. Results may not correlate with immunological protection or lack thereof, especially in immunocompromised individuals.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 53935-3
- 26643-7
- 53935-3
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 30 days |
| Frozen | 30 days |