Thyrotropin Receptor Antibody, Serum
Use
Recommended first-line test for detection of thyrotropin receptor antibodies. Used for differential diagnosis in cases of thyrotoxicosis with ambiguous clinical findings or when radioisotope scans are contraindicated. Essential in diagnosing Graves disease, assessing risk of neonatal thyrotoxicosis in pregnant women, and differentiating gestational thyrotoxicosis from manifestations of Graves disease. Also evaluates risk of Graves disease relapse after treatment.
Special Instructions
Patients must avoid multivitamins or supplements with biotin for 12 hours and should not be receiving heparin treatment prior to specimen collection. Centrifuge and aliquot serum into a plastic vial after collection.
Limitations
Presence of heterophile antibodies or antibodies to mouse can interfere with immunoassays, potentially causing inaccuracies. Assay interference may also occur with antibodies to streptavidin or ruthenium. Exercise caution when results do not match clinical presentation, and inform the laboratory to investigate discrepancies.
New York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 5385-0
- 5385-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.75 mL
Container
Serum gel preferred, Red top acceptable; Plastic vial for submission
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
Avoid multivitamins or dietary supplements containing biotin for 12 hours before collection. Do not be on heparin treatment.
Causes for Rejection
Gross hemolysis and gross icterus. Gross lipemia is acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 90 days |