TLE-1 Immunostain, Technical Component Only
Use
Transducin-like enhancer of split proteins (TLE-1) associates with chromatin, specifically with histone H3. TLE1 is upregulated in early stages of cell differentiation and may have value in the diagnosis of synovial sarcoma, where it is positive in the majority of the cases. However, this marker is not entirely specific for synovial sarcoma, and results should be interpreted in the context of other clinicopathologic and immunophenotypic features.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. The positive and negative controls are verified as showing appropriate immunoreactivity. Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
TLE-1
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred: Formalin-fixed, paraffin-embedded tissue block OR 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |