Use

Topiramate is a broad spectrum, antiepileptic drug employed for managing various types of seizures, Lennox-Gastaut syndrome, and migraine prophylaxis. This test is crucial for monitoring serum concentrations of topiramate to ensure therapeutic levels, assess patient compliance, and evaluate potential toxicity. The drug blocks voltage-dependent sodium channels, potentiates gamma-aminobutyric acid (GABA) activity, and inhibits glutamate receptors, contributing to its efficacy. Given its renal elimination, monitoring is particularly important in patients with impaired kidney function. The test assists in therapeutic drug monitoring, especially when co-administering with other medications that can affect topiramate levels, such as phenytoin and carbamazepine.