Use

The Uroporphyrinogen Decarboxylase test is primarily used for the confirmation of a diagnosis of porphyria cutanea tarda type II and hepatoerythropoietic porphyria. These are inherited disorders associated with enzyme defects in the heme biosynthetic pathway, resulting in symptoms such as cutaneous photosensitivity, chronic blistering lesions on sun-exposed skin, and liver dysfunction. The test measures the deficiency of the enzyme uroporphyrinogen decarboxylase in erythrocytes and hepatocytes, crucial for differentiating between types of porphyria and guiding treatment decisions.