Vancomycin, Peak, Serum
Use
This test is useful for monitoring peak levels in selected patients receiving vancomycin therapy. Vancomycin is an antibiotic used to treat infections caused by gram-positive organisms, especially in cases resistant to beta-lactam antibiotics, such as MRSA and penicillin-resistant strains. Monitoring vancomycin levels is important due to potential nephrotoxicity and ototoxicity risks, especially in patients with reduced renal function or at high risk for nephrotoxicity. Peak levels are primarily used for pharmacokinetic analyses.
Special Instructions
Not provided.
Limitations
The test may be interfered with by human antimouse antibodies (HAMA) in the sample, causing falsely lowered results. Rare cases of unspecific binding of heterophilic antibodies to the glucose-6-phosphate dehydrogenase reagent may result in falsely lower test results. Peak concentrations do not correlate well with efficacy or nephrotoxicity, but may aid in pharmacokinetic analysis.
Methodology
Immunoassay (ELISA)
Biomarkers
Vancomycin
Analyte
LOINC Codes
- 4090-7 - Vancomycin Peak SerPl-mCnc
- 4090-7 - Vancomycin Peak SerPl-mCnc
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Red top tube; plastic vial for submission
Collection Instructions
Serum for a peak level should be drawn 1 hour after completion of dose. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 14 days |
| Frozen | 365 days |
