Vancomycin, Random, Serum
Use
Vancomycin is an antibiotic used to treat infections caused by gram-positive organisms resistant to beta-lactam antibiotics, such as methicillin-resistant staphylococci (MRSA), Streptococcus viridans group, penicillin/cephalosporin-resistant Streptococcus pneumoniae, and penicillin/ampicillin-resistant Enterococcus species. Monitoring vancomycin levels is crucial to ensure effective treatment, prevent the development of resistance, and avoid vancomycin-related nephrotoxicity, especially in patients with renal impairment or receiving prolonged therapy.
Special Instructions
In addition to this random assay, both peak and trough level testing are available. For peak level, serum should be drawn 1 hour after dose completion; for trough level, draw no more than 30 minutes prior to the next dose.
Limitations
As with any assay employing mouse antibodies, the possibility exists for interference by human antimouse antibodies (HAMA) in the sample, possibly leading to falsely lowered results. Unspecific binding of heterophilic antibodies to glucose-6-phosphate dehydrogenase on the reagent may also lead to inaccuracies. Monitoring of patients receiving vancomycin should consider renal function and risk of nephrotoxicity when interpreting test results.
FDA ApprovedNew York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 20578-1
- 20578-1
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Red top tube; submit in plastic vial
Collection Instructions
Centrifuge and aliquot serum within 2 hours of collection.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 14 days |
| Frozen | 365 days |