VDRL Titer, Spinal Fluid
Use
The VDRL Titer test in spinal fluid aids in the diagnosis of neurosyphilis by detecting reaginic antibodies using a cardiolipin-cholesterol-lecithin antigen. This nontreponemal serologic test can indicate neurosyphilis in untreated patients by the presence of pleocytosis, elevated protein, and a positive VDRL result. The test is highly specific for diagnosing neurosyphilis when a positive result is obtained in spinal fluid.
Special Instructions
This test is only orderable as a reflex. For more information, see VDSF / VDRL, Spinal Fluid. It is crucial to submit the specimen in vial 2 if possible. If not, note which vial from which the aliquot was obtained. The test is performed Monday through Friday, and the report is available within 1 to 3 days upon receipt of the specimen.
Limitations
The VDRL test using spinal fluid specimens has a high percentage of false-negative results. Conditions such as improper specimen collection, inappropriate test selection, and interfering substances can lead to diagnostic confusion. Gross hemolysis and gross lipemia are conditions that may cause the specimen to be rejected for testing.
FDA ApprovedNew York Approved
Methodology
Other (Flocculation/Agglutination)
Biomarkers
LOINC Codes
- 31146-4
- 31146-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Plastic vial
Collection Instructions
Submit specimen collected in vial 2 if possible. If not, note which vial from which the aliquot was obtained.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |