von Willebrand Factor Multimer Analysis, Plasma
Use
This test is useful as a reflex component of several coagulation consultation unit codes when results of complementary laboratory tests are low or discordant. It is primarily used to subtype von Willebrand disease (VWD), particularly to identify variants of type 2 VWD, and to aid in determining appropriate treatment. VWD is the most common hereditary bleeding disorder, characterized by quantitative or qualitative defects in von Willebrand factor (VWF), leading to easy bruising, mucocutaneous bleeding, and post-trauma or surgical bleeding.
Special Instructions
This test is not orderable on its own and is only available as part of a coagulation reflex. Refer to the Coagulation Guidelines for Specimen Handling and Processing for more details. It should be noted when considering orders, especially in context with other tests in the coagulation spectrum.
Limitations
The von Willebrand factor multimer analysis is not useful if certain related tests are normal, such as F8A, RIST, VWACT, or VWAG. Additionally, ratios such as the vWF ristocetin cofactor to vWF antigen must not exceed 0.7, and vWF activity to vWF antigen should not exceed 0.8 for the multimer analysis to be useful.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 32217-2
- 32217-2
- 48595-3
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Container
Plasma Na Cit
Collection Instructions
For details, see the Coagulation Guidelines for Specimen Handling and Processing.
Causes for Rejection
Gross hemolysis, gross lipemia, and gross icterus will cause rejection of the specimen.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 42 days |