West Nile Serum Interpretation
Use
The test assists in the interpretation of IgM and IgG antibodies for the laboratory diagnosis of infection with West Nile virus (WNV). WNV is a mosquito-borne flavivirus that primarily infects birds but can also infect humans and horses. The infection can range from asymptomatic to West Nile fever, with severe cases potentially leading to neuroinvasive diseases or affecting older patients more severely.
Special Instructions
Laboratory diagnosis is best achieved through demonstration of specific IgG and IgM class antibodies in serum specimens. PCR tests can detect WNV RNA but have relatively low sensitivity, especially in blood. Positive results should be interpreted with caution in individuals vaccinated for flaviviruses or previously infected with related viruses.
Limitations
Results must be interpreted in conjunction with clinical evaluation and other diagnostic procedures. Negative results in immunosuppressed patients have uncertain significance. False positives may occur due to cross-reactivity with other flaviviruses or arboviruses. Specimen contamination during lumbar puncture can also cause erroneous results. Antibody levels in CSF should be carefully interpreted.
New York Approved
Methodology
Automated Analyzer
Biomarkers
LOINC Codes
- 69048-7
- 69048-7
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |