Zinc, Serum
Use
Zinc is an essential element; it is a critical cofactor for many physiologically important proteins such as carbonic anhydrase, alkaline phosphatase, RNA and DNA polymerases, and alcohol dehydrogenase. It plays a significant role in active wound healing and its deficiency can indicate dietary insufficiencies, excess loss through exudates from open wounds, or gastrointestinal losses. Zinc levels are an important indicator in conditions like anorexia, starvation, hepatic cirrhosis, ulcerative colitis, Crohn disease, and others.
Special Instructions
If gadolinium, iodine, or barium-containing contrast media have been administered, a specimen should not be collected for 96 hours. Specimen must be drawn first, avoid hemolysis, and ensure following the trace metals collection procedure.
Limitations
Hemolyzed specimens will cause false elevation of serum zinc levels. Collection through a vascular line may also result in false elevations. It is essential to follow the trace metals collection procedure carefully to avoid contamination and ensure accurate results.
New York Approved
Methodology
Mass Spectrometry (ICP-MS)
Biomarkers
LOINC Codes
- 5763-8
- 5763-8
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.8 mL
Minimum Volume
0.2 mL
Container
7-mL Mayo metal-free, screw-capped, polypropylene vial
Collection Instructions
Draw specimen first, avoid hemolysis. Let it clot for 30 minutes, centrifuge, and within 4 hours transfer serum to metal-free vial avoiding cellular components. Do not use pipet or wooden stick for transfer.
Patient Preparation
Avoid collecting specimen if gadolinium, iodine, or barium contrast media have been administered within 96 hours.
Storage Instructions
Store refrigerated or ambient for up to 28 days in metal-free container.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |