7q22/7q31 Deletion
Use
This test is designed to detect deletions in chromosome 7, specifically the regions 7q22 and 7q31. These deletions are frequently observed in myeloid and lymphoid neoplasms and can provide important diagnostic and prognostic information in conditions such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Special Instructions
All attempts will be made to process and report samples received more than 72 hours post-collection. Bone marrow is the recommended sample for most hematological malignancies.
Limitations
The test is limited by the quality of the specimen and external factors such as clotted specimens, exposure to extreme temperatures, and use of anticoagulants toxic to cells. Additionally, the sensitivity and specificity are contingent on the chromosome region targeted and the quality of the hybridization. The methodology does not allow for the detection of all potential forms of genetic mutations and is specific to deletions in the 7q22 and 7q31 regions.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |