Androgen Receptor, technical only
Use
Androgen receptor is a member of the superfamily of ligand responsive transcription regulators. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in skin. Further applicability has been shown in all histological types of prostatic carcinoma, both therapy-responsive and therapy-unresponsive. Technical component only. Pathologist read not included.
Special Instructions
Not provided.
Limitations
The test does not include a pathologist read. All other fixatives will be rejected except for 10% NBF or B plus. Specimens must be tested within 3 months after placing in ethanol. Specimen rejection criteria include other fixatives not specified. The storage stability of some specimens is indefinite under specific conditions but may vary based on preparation.
Methodology
Immunoassay (IHC)
Biomarkers
Androgen receptor
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE block
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours preferred).
Storage Instructions
Store at 15°C to 25°C. May be transferred to 70% alcohol for transportation purposes after fixation in 10% NBF or B plus.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.