beta-glucuronidase
Use
ß-glucuronidase is localized to the lysosome where it plays a critical role in the degradation of complex carbohydrates. Literature, and pathology resources demonstrate strong staining in normal liver and colon tissue, intermediate staining in normal tonsil and testis, and intermediate-to-weak staining in normal gallbladder. Overexpression may be observed across tumor types, especially B cell malignancies. All staining is shown to be localized to lysosomes in a punctate expression pattern.
Special Instructions
Fresh Tissues: Specimens may be fixed in formalin for 24-72 hours by collection sites, then transferred to 70% ethanol and stored at 2-8°C for longer term storage if needed. This is NOT preferred. Samples must be tested 3 months after placing in ethanol. Unstained slides: Positively charged glass slides required to prevent background staining and prevent tissue loss. Slides should be left unbaked.
Limitations
Biopharma test is available for use in clinical trials or research purposes only. Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected. Stated turnaround times are for clinical use only and subject to change based on biopharma protocol requirements.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE Block, Formalin Fixed
Storage Instructions
Ambient, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |