Use

ß-glucuronidase is localized to the lysosome where it plays a critical role in the degradation of complex carbohydrates. Literature, and pathology resources demonstrate strong staining in normal liver and colon tissue, intermediate staining in normal tonsil and testis, and intermediate-to-weak staining in normal gallbladder. Overexpression may be observed across tumor types, especially B cell malignancies. All staining is shown to be localized to lysosomes in a punctate expression pattern.