CBFB::MYH11; t(16;16) / inv(16)
Use
This FISH test is utilized for the detection of CBFB gene rearrangement, which is frequently observed in acute myeloid leukemia (AML). It helps in the identification of genetic abnormalities associated with AML, aiding in diagnosis, prognosis, and treatment decisions. It is particularly relevant for hematologic specimens and is a part of routine evaluations for patients suspected of AML.
Special Instructions
All attempts will be made to process and report samples received more than 72 hours post-collection. Bone marrow is considered the sample of choice in most hematologic malignancies associated with this test.
Limitations
The test is limited by the stability of specimens, which should be processed within 72 hours. Any delays beyond this window may affect the accuracy and reliability of the results. Additionally, clotted specimens or those exposed to extreme temperatures can lead to rejection, affecting test outcomes.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |