CDX2, technical only
Use
CDX2 is a transcription factor expressed early in intestinal development and may also be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. Loss of CDX2 has been shown to contribute to the progression of some colorectal cancers, distinguishing between primary and secondary colorectal cancer, and is a marker for GI origin of adenocarcinomas. Technical component only. Pathologist read not included.
Special Instructions
Fresh Tissues should be fixed in formalin for 24-72 hours; can be stored in ethanol for longer periods if necessary. Unstained slides must be positively charged to prevent background staining and tissue loss. Avoid baking slides.
Limitations
This test is limited to technical analysis and does not include a pathologist read. Results may vary based on sample quality and fixation process. Specimens not fixed in 10% NBF or B Plus are subject to rejection.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Storage Instructions
15°C to 25°C. Ambient with a refrigerated gel pack if necessary.
Causes for Rejection
Specimens must be fixed in 10% NBF or B Plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours for fresh tissues. |