cMET
Use
c-MET (SP44) is a rabbit monoclonal antibody against the carboxyl region of the tyrosine kinase, transmembrane c-MET protein. Dysregulated c-MET expression has been observed at both protein and mRNA levels in a variety of human carcinomas and sarcomas and is associated with EGFR inhibitor resistance in lung cancer as well as poor patient outcome. No clear relationship has yet been discovered between the expression of MET protein and c-MET mRNA.
Special Instructions
Fresh tissues should be at a 20:1 fixative to tissue ratio, fixed in 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours preferred). Unstained slides should be positively charged glass slides required to prevent background staining and tissue loss and should be left unbaked.
Limitations
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract. Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours preferred).
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours |