Gastrin
Use
Gastrin is a polypeptide hormone crucial for digestive functions. It is naturally occurring in three forms: gastrin-14, gastrin-17, and gastrin-34. Its measurement aids in diagnosing disorders characterized by G-cell hyperplasia, including Zollinger-Ellison syndrome and G-cell hypersecretion. Understanding these levels can help address conditions related to hypergastrinemia and guide in clinical diagnosis of gastric disorders.
Special Instructions
Specimens may be fixed in formalin for 24-72 hours and then transferred to 70% ethanol for storage at 2-8°C. Unstained slides should use positively charged glass to prevent tissue loss and unbaked to avoid background staining.
Limitations
Specimens using any fixatives other than 10% neutral buffered formalin or B plus will be rejected. Final turnaround times may vary based on biopharma protocol requirements. Testing should be completed within 3 months after placing in ethanol for best results. Turnaround time is subject to change and will be determined by study contract.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
8 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin for 6-72 hours (48-72 hours PREFERRED). For long-term storage, transfer to 70% ethanol.
Storage Instructions
Store at 15°C to 25°C. Shipping should be ambient with a refrigerated gel pack to avoid extreme temperatures. Use of 70% alcohol is acceptable after initial fixation.
Causes for Rejection
Specimens fixed in any other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 Hours |
| Refrigerated | Indefinite |
| Frozen | Indefinite |