IGH::MAF; t(14;16)
Use
The IGH::MAF FISH test is used to detect the gene fusion between IGH and MAF, associated with the translocation t(14;16). This fusion is linked with multiple myeloma, monoclonal gammopathy, and plasma cell leukemia. It is conducted on hematologic specimens to identify the presence of this specific chromosomal abnormality.
Special Instructions
All attempts will be made to process and report samples received more than 72 hours post-collection. Bone marrow is the sample of choice in most hematologic malignancies, although whole blood can also be used.
Limitations
Results from FISH analysis must be interpreted in conjunction with clinical and laboratory findings. The test is an ASR, not cleared or approved by the FDA, and is intended for research purposes only. The detection of IGH::MAF fusion does not confirm the presence or absence of any other genetic abnormalities.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells