INI-1
Use
INI-1 germline mutations are associated with rhabdoid tumor predisposition syndrome 1 and familial schwannomatosis. Loss of INI-1 expression is identified in a variety of rhabdoid and non-rhabdoid neoplasms of the CNS, soft tissue and parenchymal / visceral organs.
Special Instructions
For fresh tissues, specimens may be fixed in formalin for 24-72 hours by collection sites, then transferred to 70% ethanol and stored at 2-8°C for longer-term storage if needed. Unstained slides require positively charged glass slides to prevent background staining and tissue loss, and should be left unbaked.
Limitations
Specimens fixed in other than 10% NBF or B plus will be rejected. The test is available for use in clinical trials or research purposes only.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE Block, Formalin Fixed
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours preferred).
Storage Instructions
Store at 15°C to 25°C.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |