PD-1, technical only
Use
PD-1 functions as an inhibitory cell surface receptor on T-cells and B-cells, and is important for peripheral tolerance. PD-L1 and PD-L2 are ligands of the PD-1 receptor. This test is technical component only, meaning it does not include pathologist interpretation.
Special Instructions
Fresh tissues should be fixed in 10% neutral buffered formalin for 6-72 hours, with preference for 48-72 hours. Unstained slides require positively charged glass slides to prevent background staining and tissue loss. Samples must be tested within 3 months if stored in ethanol.
Limitations
Technical only test; pathologist read is not included. Turnaround times are subject to change based on biopharma protocol requirements and will be specified in the biopharma study contract.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, using 10% neutral buffered formalin for 6-72 hours (48-72 hours preferred).
Storage Instructions
15°C to 25°C for fresh tissues, ambient shipping.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours |