SOX10
Use
SOX10 is a transcription factor that plays a crucial role in the development of neural crest cells and is widely used in pathology to identify neural crest-derived tumors. It is particularly valuable in diagnosing melanoma, schwannomas, and peripheral nerve sheath tumors, where its expression helps distinguish these from other neoplasms. SOX10 is also used to assess tumor differentiation, and its presence in certain tumors can aid in determining the prognosis and guiding therapeutic decisions.
Special Instructions
Fresh Tissues: Specimens may be fixed in formalin for 24-72 hours by collection sites, then transferred to 70% ethanol and stored at 2-8°C for longer term storage if needed. Samples must be tested 3 months after placing in ethanol. Unstained slides: Positively charged glass slides required to prevent background staining and prevent tissue loss. Slides should be left unbaked.
Limitations
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.