SOX11
Use
SOX11 is a transcription factor involved in the development of various tissues and is used in pathology for identifying tumors of neural or mesenchymal origin. It is particularly useful for diagnosing malignant peripheral nerve sheath tumors (MPNSTs), as it is highly expressed in these tumors but not in benign schwannomas or other soft tissue tumors. SOX11 also helps distinguish certain types of B-cell lymphomas, such as mantle cell lymphoma.
Special Instructions
Samples must be tested 3 months after placing in ethanol. Positively charged glass slides required to prevent background staining and prevent tissue loss. Slides should be left unbaked.
Limitations
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract. Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected. SOX11 is not expressed in benign schwannomas or other soft tissue tumors.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE Block, Formalin Fixed
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED). Specimens may be transferred to 70% alcohol for transportation purposes after fixation in 10% NBF or B plus.
Storage Instructions
Ambient; Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Stored at 15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | Indefinite |