Synaptophysin
Use
Synaptophysin is a membrane glycoprotein expressed in the synaptic vesicles of neurons and neuroendocrine cells. It is primarily used in pathology to identify neuroendocrine tumors, including neuroblastomas, small cell carcinomas, and pheochromocytomas, as these tumors typically show strong synaptophysin expression. This marker also helps differentiate neuroendocrine tumors from other types of malignancies with similar histological features.
Special Instructions
Fresh tissues should be fixed in formalin for 24-72 hours by collection sites, then transferred to 70% ethanol and stored at 2-8°C for longer-term storage if needed. Positively charged glass slides required to prevent background staining and prevent tissue loss. Slides should be left unbaked.
Limitations
Specimens must be fixed in 10% neutral buffered formalin or B plus. All other fixatives will be rejected. The stated turnaround times are for clinical use only and subject to change based on biopharma protocol requirements.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE Block, Formalin Fixed
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |