T-cell Receptor Gamma Gene Rearrangement
Use
This assay is used to detect clonal T-cell rearrangements to assist in the diagnosis of T-cell lymphoma, providing critical information for the clinical management of patients suspected of having this condition.
Special Instructions
Frozen bone marrow samples are NOT accepted. Paraffin Embedded Tissue Block: FFPE block preferred; unbaked slides acceptable. Extracted DNA: Isolation of nucleic acids for clinical testing must occur in a CLIA-certified laboratory or a laboratory meeting equivalent requirements. Concentration and volume must be provided for all samples.
Limitations
The test is used primarily for detection of clonal T-cell populations and may not detect all types of T-cell lymphomas. It is essential for the specimen volume and type to meet the specified requirements to avoid inaccurate results. Improper specimen handling or storage can lead to degradation of genetic material, making the results invalid.
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5mL
Minimum Volume
3mL
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 8°C
Causes for Rejection
Improper specimen labeling; Insufficient sample volume; Clotted specimen; Specimens beyond stability; Insufficient DNA isolated
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | 30 Days |
| Frozen | Long Term |