GeneSight

Casandra

Casandra Test Code MG11233Version 1 (DRAFT)

Performing Lab

Lab Myriad GeneticsLab Test ID N/ACPT Code 0011M

Clinical Use

Use

GeneSight® Psychotropic is a pharmacogenomic test intended to help inform medication selection and treatment decisions for psychiatric medications by identifying potential gene–drug interactions based on a patient’s genetic results. Results are intended to supplement other clinical and patient-specific factors considered by a healthcare provider during a comprehensive medical assessment. It evaluates pharmacokinetic and pharmacodynamic genes and provides report-based medication categorization and clinical considerations when applicable.

Special Instructions

Test must be ordered by a registered clinician. Collect a cheek (buccal) swab using the provided collection kit (in-office or at-home collection kit). Submit the sample per kit instructions and required paperwork as applicable. Results are delivered through the GeneSight clinician report workflow once the laboratory receives the specimen.

Limitations

GeneSight® Psychotropic does not identify which medication will work for a patient and does not replace clinical judgment. Medication response is multifactorial; non-genetic factors (e.g., drug–drug interactions, diet, age, environment, and other clinical factors) may affect outcomes and are not captured by the test. Genetic results do not change based on current medications. Some medications may have “No Proven Genetic Markers,” meaning genetic markers have not yet been discovered to reliably categorize them.

Test Details

Methodology

PCR-based (PCR)

Biomarkers

Haplotype / Allele (8 genes)

CYP2D6CYP2C19CYP2C9CYP1A2CYP3A4CYP3A5HTR2ASLC6A4

HLA-A

Gene

Allele Presence

Haplotype / Allele • Categorical (e.g., Positive / Negative / Indeterminate)

Result Turnaround Time

2 days

Specimen Collection Options

This test supports the following collection methods

Kit
PSC (Patient Service Center)
Physician Office
Mobile Phlebotomy

Specimen Requirements

Specimen

Buccal Swab

Volume

Two swabs

Minimum Volume

Not provided

Container

Buccal (cheek) swab collection kit (two cheek swabs)

Collection Instructions

Rub the swab along the inside of the cheek for ~10 seconds; repeat on the other cheek with the second swab. Package the swabs per kit instructions and return the sample.