AAT
Also known as: alpha-1-antitrypsin
Use
Alpha‑1‑Antitrypsin (AAT) immunohistochemistry (IHC) is used in evaluating inherited AAT deficiency and distinguishing benign versus malignant hepatic tumors and yolk sac carcinoma. Its sensitivity and specificity render it valuable for screening patients with cryptogenic cirrhosis or unexplained portal fibrosis in liver disease.
Special Instructions
Level of Service: Technical Only. “New York Approved: Yes” indicates New York approval. Turnaround time is 24 Hours. Specimen requirements include a formalin-fixed, paraffin‑embedded (FFPE) tissue block or one unbaked unstained slide for H&E staining (required) plus two to three positively charged unstained slides (4‑5 microns) per test. Storage: transport with cold pack not in direct contact; NYS clients must provide date and time of collection.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block preferred; or one unbaked, unstained slide for H&E (required) plus two to three positively charged unstained slides (4‑5 microns) for each test/antibody.
Storage Instructions
Transport with cold pack, not in direct contact with specimen.