B-Cell Gene Rearrangement
Also known as: B-Cell Translocations
Use
B-Cell gene rearrangement testing is used for identifying clonal B cell populations, which are highly suggestive of B cell malignancies. This assay is useful in the diagnosis, staging or monitoring of various lymphomas and other B-cell lymphoproliferative diseases, however, not all clonal populations are malignant. Also, a negative result does not entirely exclude the presence of a clonal B-cell immunoglobulin gene rearrangement. Up to 20% of B-cell lymphoproliferative disorders can be negative by PCR evaluation. So, the results from this test must be interpreted within the context of clinical, morphologic and immunophenotypic findings.
Special Instructions
Not provided.
Limitations
Not all clonal B cell populations identified are malignant. Up to 20% of B-cell lymphoproliferative disorders may be negative by PCR evaluation, which means results need to be interpreted in conjunction with other clinical, morphologic, and immunophenotypic findings.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
IgH
Other
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA tube