Casandra
Casandra Test Code NG07315Version 1 (DRAFT)
Performing Lab
BTK Inhibitor Acquired Resistance Panel
Also known as: BTK, BTK acquired resistance
Clinical Use
Order TestUse
This panel detects mutations in BTK and PLC‑gamma‑2 which are associated with acquired ibrutinib resistance in certain B‑cell neoplasms. It is appropriate for patients with B‑cell neoplasms who have relapsed and/or show acquired (secondary) resistance after an initial response to BTK (Bruton tyrosine kinase) inhibitors.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
NGS (Targeted)
Biomarkers
BTK, PLCG2
GeneSNV/Indel
Mutation • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
10 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA tube
Storage Instructions
Use cold pack for transport; refrigerate before shipping and ship same day; do not freeze.