Caldesmon
Use
Caldesmon is a regulatory protein found in smooth muscle and tissues, interacting with actin, myosin, tropomyosin and calmodulin. Detection by immunohistochemistry aids in identifying smooth muscle differentiation as well as tumors with smooth muscle, myofibroblastic, and myoepithelial characteristics. It is also clinically useful in distinguishing epithelioid mesothelioma from serous papillary carcinoma of the ovary.
Special Instructions
Technical Only level of service. A formalin-fixed, paraffin‑embedded (FFPE) tissue block is preferred, or one unbaked unstained slide for H&E staining (required) plus 2–3 positively charged unstained slides (4–5 μm) per test. Block and slide IDs must match requisition. Use cold pack for transport without direct contact with specimen; New York State (NYS) clients should include date and time of collection.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block preferred; or one unbaked unstained slide for H&E plus two to three positively charged unstained slides (4‑5 µm). Slide/block identifiers must match the requisition.
Storage Instructions
Use cold pack for transport; cold pack not to contact specimen. NYS clients: provide date and time of collection.