Carbonic Anhydrase IX (CA IX)
Use
Carbonic anhydrase IX (CA IX) is a cell surface transmembrane protein predominantly found in the gastrointestinal tract and gall bladder. In adenocarcinoma, glandular regions of the colon become positive, while in normal colon they are negative. CA IX is also expressed in epithelial tumors including carcinomas of the esophagus, lung, colon, kidney (clear cell renal carcinoma), cervix, and non‑small cell lung carcinoma (NSCLC). It is absent in normal kidney, chromophobe carcinomas, and oncocytomas, making it a useful marker to distinguish clear cell renal carcinomas from other renal neoplasms.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Carbonic Anhydrase IX (CA IX)
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred; or one unbaked, unstained slide for H&E (required) and two to three positively charged unstained slides (cut at 4‑5 microns) per test.
Storage Instructions
Use cold pack for transport, not in direct contact with specimen. NYS clients: provide date and time of collection.