CBFB (16q22)
Use
This assay detects structural rearrangements—specifically inversion of chromosome 16 [inv(16)] and translocation t(16;16)—in the CBFB gene, which are associated with acute myeloid leukemia (AML), including the M4E variant (acute myelomonocytic leukemia / AML‑M4E), aiding diagnosis and classification.
Special Instructions
Level of Service options include Global and Tech Only. Note for New York State clients: specimens should include date and time of collection. Avoid including biopsy needles, blades, or other foreign objects in transport tubes. Storage and transport: use a cold pack not in direct contact with the specimen.
Limitations
Not provided.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1‑2 mL
Minimum Volume
Not provided
Container
Sodium Heparin Tube (EDTA acceptable)
Collection Instructions
Bone Marrow Aspirate: 1‑2 mL in sodium heparin tube; EDTA tube acceptable
Storage Instructions
Use cold pack for transport, not in direct contact with specimen
Causes for Rejection
Include date/time for NYS; exclude biopsy needles, blades, foreign objects