Use

Carcinoembryonic antigen (CEA) is typically demonstrated as a linear labeling of the apical poles of glandular epithelial cells, and occasionally as weak apical cytoplasmic staining in normal colonic epithelium. Tumors usually exhibit increased cytoplasmic staining. In diagnostic contexts, CEA IHC can be useful for identifying pancreatic carcinomas, testicular tumors, gallbladder neoplasms, and granular cell myoblastomas, which are generally positive, whereas malignant tumors of the brain, prostate, skin, lymphoreticular tissues, hepatocellular carcinoma, esophageal squamous cell carcinoma, and mesothelioma are typically negative.