CK7
Also known as: Cytokeratin 7
Use
Cytokeratin 7 (CK7) antibody reacts with proteins found in most ductal, glandular, and transitional epithelium of the urinary tract and bile duct epithelial cells. CK7 helps distinguish lung and breast epithelium (which stain positive) from colon and prostate epithelial cells (which are negative). It also reacts with many benign and malignant epithelial lesions, such as adenocarcinomas of the ovary, breast, and lung. Transitional cell carcinomas are positive and most prostate cancers are negative.
Special Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is the preferred specimen type. Alternatively, one unbaked, unstained slide for H&E staining (required) and two to three positively charged unstained slides (all cut at 4‑5 microns) are accepted. Block and slide identifiers should be clearly written and match exactly with specimen ID and requisition labels. During transport, use a cold pack not in direct contact with the specimen. New York State clients must provide date and time of collection.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit FFPE tissue block, or one unbaked unstained H&E slide plus two to three positively charged unstained slides (4‑5 microns).
Storage Instructions
Use cold pack for transport; ensure cold pack is not in direct contact with specimen.
Causes for Rejection
Block and slide identifiers must match exactly with specimen ID and labels.