H3K27me3
Use
H3K27me3 (trimethylation at lysine 27 of histone H3) is involved in the modification of DNA by protein Histone H3. Complete loss of H3K27me3 expression by immunohistochemistry can be useful in the diagnosis of malignant peripheral nerve sheath tumors (MPNST). Clone: C36B11; Staining pattern: Nuclear.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
H3K27me3
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides (cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.