IgG4 (Immunoglobulin G4)
Use
Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the pancreatic duct and can mimic carcinoma. Pancreatic tissue from patients with autoimmune pancreatitis often shows moderate or marked infiltration by IgG4‑positive plasma cells. IgG4 staining is rarely observed in chronic alcoholic pancreatitis and pancreatic ductal adenocarcinoma, making IgG4‑positive plasma cells a useful marker for tissue diagnosis of autoimmune pancreatitis. An elevated IgG4+ to IgG+ plasma cell ratio (IgG4/IgG ratio) is helpful in distinguishing IgG4‑related from non‑IgG4‑related inflammatory conditions.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
IgG4
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides (all cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.