Kappa ISH
Use
This test targets the kappa light chain immunoglobulin mRNA in the cytoplasm of immunoblastic, plasma, and plasmacytoid cells. It aids in the diagnosis of malignant lymphoma by assessing light chain immunoglobulin restriction, thus helping to distinguish between neoplastic and reactive lymphoid proliferations. It is valuable in evaluating multiple myeloma, plasmacytoma, lymphomas with plasmacytoid features, immunoblastic lymphomas, and reactive plasma cell proliferations.
Special Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is the preferred specimen type. The block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Limitations
The test evaluates light chain restriction to assist in distinguishing between types of lymphoid proliferations but may have limitations in cases where mRNA expression is low or absent due to sample quality or preparation. It relies on proper specimen handling and preparation.
New York Approved
Methodology
Chromosomal / Cytogenetics (ISH)
Biomarkers
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.