Use

MLH1 is a mismatch repair protein involved in maintaining the integrity of genetic information. It works alongside MSH2, MSH6, and PMS2. Mutations in the MLH1 gene can lead to defects in DNA repair pathways, which are linked to human carcinogenesis. These mutations have been reported in tumors with microsatellite instability (MSI) such as hereditary nonpolyposis colon cancer (HNPCC), some sporadic carcinomas, breast cancer, acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma, and ovarian carcinoma.