Casandra
Casandra Test Code NG38306Version 1 (DRAFT)
Performing Lab
MLH1 Promoter Methylation Analysis
Also known as: MLH1 Methylation
Clinical Use
Order TestUse
This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Analysis should be considered with IHC, BRAF, and/or MSI to gain comprehensive insights into tumor genetics.
Special Instructions
Not provided.
Limitations
The detection of hypermethylation is limited to the MLH1 gene promoter, and results are reported as a percentage of methylated DNA. Interpretation should be integrated with additional analyses such as IHC, BRAF, and/or MSI.
Test Details
New York Approved
Methodology
PCR-based (RT-PCR)
Biomarkers
Promoter Methylation Analysis • RT-PCR
Result Turnaround Time
10 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Paraffin block or 1 H&E slide plus 5-10 unstained slides
Storage Instructions
Use cold pack for transport, ensuring no direct contact with specimen.