Casandra
Casandra Test Code NG18548Version 1 (DRAFT)
Performing Lab
MPL Mutation Analysis by NGS
Clinical Use
Order TestUse
Exon 10 MPL mutations, most commonly W515 and S505, are present in approximately 5‑10% of patients with primary myelofibrosis (PMF) and essential thrombocythemia (ET). MPL and CALR mutations have been associated with increased risk of myelofibrotic transformation in ET cases. (References: PMID: 36347013)
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
NGS (Targeted)
Biomarkers
MPL
GeneSNV/Indel
Mutation • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Bone Marrow
Volume
1‑2 mL in EDTA tube
Minimum Volume
Not provided
Container
EDTA tube (Sodium Heparin acceptable)
Storage Instructions
Refrigerate before shipping, ship same day; use cold pack not in direct contact; do not freeze