NeoTYPE® DNA & RNA - Brain
Also known as: Brain Tumor Profile
Use
NeoTYPE® DNA & RNA - Brain uses targeted next-generation sequencing (NGS) to detect single nucleotide variants, insertions/deletions, and gene fusions in 83 unique genes total (62 DNA, 28 RNA; overlapping targets included), plus microsatellite instability (MSI) and tumor mutational burden (TMB). Results provide diagnostic, prognostic, and therapeutic implications, as well as potential clinical trial options. Potential reflex testing for MSI by PCR is performed if MSI NGS results are indeterminate and conditions are met.
Special Instructions
MGMT Promoter Methylation Analysis by PCR is an optional add-on.
Limitations
If the sample is insufficient to produce both DNA and RNA results, the available results will be reported and alternate CPT codes may apply. Additionally, the use of zinc fixatives for specimen preservation is not recommended.
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
10mm2
Container
Paraffin block or unstained slides
Collection Instructions
Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
