NeoTYPE® MDS/CMML Profile
Also known as: MDS/CMML Profile
Use
The NeoTYPE MDS/CMML Profile analyzes genes frequently mutated in myelodysplastic syndrome (MDS) and the related MDS/MPN overlap disease chronic myelomonocytic leukemia (CMML). Testing is useful to establish diagnosis and develop strategies for treatment and management, as mutations can signify poor or favorable prognosis and they inform of the underlying disease biology. Molecular profiling in MDS and CMML complements and should be interpreted with cytogenetic/FISH test findings. This Profile may also be used in AML cases that evolved from MDS, therapy-related AML, and AML with myelodysplasia.
Special Instructions
Test Customization: FLT3 by PCR (via FLT3 Mutation Analysis) is available for concurrent testing as a Client-Bill option. It is reported separately to support prompt therapy selection in newly diagnosed AML cases. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. NYS clients, please provide date and time of collection. Please select Extract & Hold - TNA if specimen hold service is desired.
Limitations
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Paraffin block is preferred for FFPE; do not use zinc fixatives. FFPE slides should use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match the specimen ID as noted on the requisition.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
14 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA tube