NeoTYPE® MDS/CMML Profile

Also known as: MDS/CMML Profile

Clinical Use

Use

The NeoTYPE MDS/CMML Profile analyzes genes frequently mutated in myelodysplastic syndrome (MDS) and the related MDS/MPN overlap disease chronic myelomonocytic leukemia (CMML). Testing is useful to establish diagnosis and develop strategies for treatment and management, as mutations can signify poor or favorable prognosis and they inform of the underlying disease biology. Molecular profiling in MDS and CMML complements and should be interpreted with cytogenetic/FISH test findings. This Profile may also be used in AML cases that evolved from MDS, therapy-related AML, and AML with myelodysplasia.

Special Instructions

Not provided.

Limitations

Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Paraffin block is preferred for FFPE; do not use zinc fixatives. FFPE slides should use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match the specimen ID as noted on the requisition.

Test Details

New York Approved

Methodology

NGS (Targeted)

Biomarkers

Mutation (45 genes)

CSF3RDNMT3AETV6EZH2HRASCALRIDH2KITIDH1KRASNPM1NRASPHF6PIGAPTPN11RUNX1SETBP1SF3B1SRSF2STAG2TET2U2AF1WT1ZRSR2DDX41MPLPPM1DNF1BCORL1CBLCUX1ETNK1FLT3GNB1STAT3JAK2STAT5BGATA2PDGFRAPTENTP53ASXL1BCORBRAFCEBPA