Casandra
Casandra Test Code NG33079Version 1 (DRAFT)
Performing Lab
NPM1 Mutation Analysis
Also known as: Nucleophosmin (Nucleolar Phosphoprotein B23)
Clinical Use
Order TestUse
Testing for NPM1 and other gene mutations in AML patients with intermediate-risk cytogenetic abnormalities can improve risk stratification. NPM1 mutations can predict favorable prognosis in AML with normal karyotype.
Special Instructions
Not provided.
Limitations
The test is optimized for detecting small insertion mutations specific to AML in exon 12 of NPM1. The process requires precise handling of specimens and may not be suitable for samples with incompatible fixatives.
Test Details
Methodology
PCR-based (PCR)
Biomarkers
No genes
GeneSNVs + Indels
Mutation • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA tube
Storage Instructions
Use cold pack for transport. Refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze.