NSE (Neuron Specific Enolase)
Use
Neuron Specific Enolase (NSE) is an immunohistochemical marker expressed in neurons and various neuroendocrine tissues. It helps detect tumors of neuroendocrine origin, including ganglioneuromas, neuroblastomas, Schwannomas, malignant melanomas, pheochromocytomas, paragangliomas, carcinoids, medullary thyroid carcinomas, pituitary adenomas, endocrine tumors of the pancreas and gastrointestinal tract, as well as neuroendocrine carcinoma of the skin (Merkel cell tumor) and small cell carcinoma of the lung. It assists pathologists in identifying neuroendocrine differentiation in tissue samples.
Special Instructions
Level of service is Tech Only. For New York State clients, collection date and time must be provided. Block and slide identifiers must exactly match the specimen ID and requisition. Use cold pack transport without direct contact between the pack and specimen.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred. Alternatively, one unbaked, unstained slide for H&E staining (required) plus two to three positively charged unstained slides, all cut at 4–5 microns.