NTRK & RET NGS Fusion Panel
Also known as: NTRK & RET NGS Fusion Profile
Use
The NTRK & RET NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes NTRK1, NTRK2, NTRK3, and RET, including known and novel fusion partners. It also detects point mutations in select exons of these genes. This test may be utilized to select patients for FDA-approved therapies, such as ROZLYTREK® (entrectinib) and VITRAKVI® (larotrectinib) for NTRK, and GAVRETO (pralsetinib) and RETEVMO (selpercatinib) for RET.
Special Instructions
Not provided.
Limitations
Results may vary based on specimen quality and handling. Zinc fixatives should not be used as they can affect results.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
21 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Paraffin block or slides
Collection Instructions
1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Use positively-charged slides and 10% NBF fixative.
Storage Instructions
Use cold pack for transport.
Causes for Rejection
Use of zinc fixatives.