OCT2
Use
Octamer Binding Transcription Factor 2 (OCT2) is present in all B‑cells expressing immunoglobulin. The combination of BOB1 and OCT2 stains is helpful in distinguishing classical Hodgkin lymphoma (where at least one marker is negative) from nodular lymphocyte predominant Hodgkin lymphoma (both markers expressed). In classical Hodgkin lymphoma, staining patterns are BOB1− OCT2+ or BOB1+ OCT2−, whereas nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) or diffuse large B‑cell lymphoma (DLBCL) stains BOB1+ OCT2+.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
FFPE tissue block preferred; or one unbaked, unstained H&E slide (required) and two to three positively charged unstained slides (cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers must match requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For NYS clients provide date and time of collection.